Author: Jun Wu; Dingyun Song; Zhongwen Li; Baojie Guo; Yani Xiao; Wenjing Liu; Lingmin Liang; Chunjing Feng; Tingting Gao; Zai Wang; Jianyan Wen; Shengnan Yang; Peipei Liu; Lei Wang; Yukai Wang; Liang Peng; Guihai Feng; Shiqiang Huang; Glyn Nigel Stacey; Wei Li; Yan Huo; Ronghua Jin; Qi Zhou; Liu Wang; Baoyang Hu; Huaping Dai; Jie Hao
Title: Immunity-and-Matrix-Regulatory Cells Derived from Human Embryonic Stem Cells Safely and Effectively Treat Mouse Lung Injury and Fibrosis Document date: 2020_4_16
ID: 8dpla6jt_85
Snippet: However, to the best of our knowledge and in spite of significant effort by numerous groups, previously 561 reported studies lacked biosafety-related experiments. This has hindered their translation to clinical 562 application. To ensure safety, a series of biosafety-related experiments were performed according to the 563 "Guidelines for Human Somatic Cell Therapies and Quality Control of Cell-based Products" and the 564 IMRCs were verified as su.....
Document: However, to the best of our knowledge and in spite of significant effort by numerous groups, previously 561 reported studies lacked biosafety-related experiments. This has hindered their translation to clinical 562 application. To ensure safety, a series of biosafety-related experiments were performed according to the 563 "Guidelines for Human Somatic Cell Therapies and Quality Control of Cell-based Products" and the 564 IMRCs were verified as suitable for use in human therapy. Our data showed that there was no teratoma 565 formation observed after IMRCs injection into the testes of NOD-SCID mice. In addition, single cell 566 RNA sequencing data showed no residual hESCs were detected in IMRCs and soft agar assays also 567 author/funder. All rights reserved. No reuse allowed without permission.
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