Immuno-informatics Characterization SARS-CoV-2 Spike Glycoprotein for Prioritization of Epitope based Multivalent Peptide Vaccine

Saba Ismail; Sajjad Ahmad; Syed Sikander Azam

Both primary and secondary immune responses seem to play a significant contribution against the pathogen and may be compatible to the actual immune response. The in silico host immune system response to the antigen is shown in Fig.8 . High concentration of IgG +IgG and IgM was characterized at the primary response, followed by IgM, IgG1+ IgG2 and IgG1 at both primary and secondary stages with concomitant of antigen reduction. Additionally, robust response of interleukins and cytokines were observed. All this suggest the efficient immune response and clearance of the pathogen upon subsequent encounters. Elevated B cell population including memory cells and different isotypes in response to the antigen, points to the long lasting formation of memory and isotype switching. The T helper cell population additionally with the cytotoxic T cell and their respective memory development are in strong agreement of strong response to the antigen. author/funder. All rights reserved. No reuse allowed without permission.