Advances and Perspectives in Dental Pulp Stem Cell Based Neuroregeneration Therapies

Luzuriaga, Jon; Polo, Yurena; Pastor-Alonso, Oier; Pardo-Rodríguez, Beatriz; Larrañaga, Aitor; Unda, Fernando; Sarasua, Jose-Ramon; Pineda, Jose Ramon; Ibarretxe, Gaskon

Human dental pulp stem cells (hDPSCs) are some of the most promising stem cell types for regenerative therapies given their ability to grow in the absence of serum and their realistic possibility to be used in autologous grafts. In this review, we describe the particular advantages of hDPSCs for neuroregenerative cell therapies. We thoroughly discuss the knowledge about their embryonic origin and characteristics of their postnatal niche, as well as the current status of cell culture protocols to maximize their multilineage differentiation potential, highlighting some common issues when assessing neuronal differentiation fates of hDPSCs. We also review the recent progress on neuroprotective and immunomodulatory capacity of hDPSCs and their secreted extracellular vesicles, as well as their combination with scaffold materials to improve their functional integration on the injured central nervous system (CNS) and peripheral nervous system (PNS). Finally, we offer some perspectives on the current and possible future applications of hDPSCs in neuroregenerative cell therapies.