Selected article for: "acute sars and long hospitalization"
Author: Kurth, Florian; Roennefarth, Maria; Thibeault, Charlotte; Corman, Victor M.; Müller-Redetzky, Holger; Mittermaier, Mirja; Ruwwe-Glösenkamp, Christoph; Heim, Katrin M.; Krannich, Alexander; Zvorc, Saskia; Schmidt, Sein; Kretzler, Lucie; Dang-Heine, Chantip; Rose, Matthias; Hummel, Michael; Hocke, Andreas; Hübner, Ralf H.; Opitz, Bastian; Mall, Marcus A.; Röhmel, Jobst; Landmesser, Ulf; Pieske, Burkert; Knauss, Samuel; Endres, Matthias; Spranger, Joachim; Mockenhaupt, Frank P.; Tacke, Frank; Treskatsch, Sascha; Angermair, Stefan; Siegmund, Britta; Spies, Claudia; Weber-Carstens, Steffen; Eckardt, Kai-Uwe; Schürmann, Dirk; Uhrig, Alexander; Stegemann, Miriam S.; Zoller, Thomas; Drosten, Christian; Suttorp, Norbert; Witzenrath, Martin; Hippenstiel, Stefan; von Kalle, Christof; Sander, Leif Erik
Title: Studying the pathophysiology of coronavirus disease 2019: a protocol for the Berlin prospective COVID-19 patient cohort (Pa-COVID-19)
  • Cord-id: m6ak0k8r
  • Document date: 2020_6_13
    • ID: m6ak0k8r
    Snippet: PURPOSE: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide causing a global health emergency. Pa-COVID-19 aims to provide comprehensive data on clinical course, pathophysiology, immunology and outcome of COVID-19, to identify prognostic biomarkers, clinical scores, and therapeutic targets for improved clinical management and preventive interventions. METHODS: Pa-COVID-19 is a prospective observational cohort study of patients with confirmed SARS-CoV-2 infection tr
    Document: PURPOSE: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide causing a global health emergency. Pa-COVID-19 aims to provide comprehensive data on clinical course, pathophysiology, immunology and outcome of COVID-19, to identify prognostic biomarkers, clinical scores, and therapeutic targets for improved clinical management and preventive interventions. METHODS: Pa-COVID-19 is a prospective observational cohort study of patients with confirmed SARS-CoV-2 infection treated at Charité - Universitätsmedizin Berlin. We collect data on epidemiology, demography, medical history, symptoms, clinical course, and pathogen testing and treatment. Systematic, serial blood sampling will allow deep molecular and immunological phenotyping, transcriptomic profiling, and comprehensive biobanking. Longitudinal data and sample collection during hospitalization will be supplemented by long-term follow-up. RESULTS: Outcome measures include the WHO clinical ordinal scale on day 15 and clinical, functional, and health-related quality-of-life assessments at discharge and during follow-up. We developed a scalable dataset to (i) suit national standards of care, (ii) facilitate comprehensive data collection in medical care facilities with varying resources, and (iii) allow for rapid implementation of interventional trials based on the standardized study design and data collection. We propose this scalable protocol as blueprint for harmonized data collection and deep phenotyping in COVID-19 in Germany. CONCLUSION: We established a basic platform for harmonized, scalable data collection, pathophysiological analysis, and deep phenotyping of COVID-19, which enables rapid generation of evidence for improved medical care and identification of candidate therapeutic and preventive strategies. The electronic database accredited for interventional trials allows fast trial implementation for candidate therapeutic agents. TRIAL REGISTRATION: Registered at the German registry for clinical studies (DRKS00021688) ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s15010-020-01464-x) contains supplementary material, which is available to authorized users.

    Search related documents:
    Co phrase search for related documents
    • activation composition and acute respiratory: 1, 2, 3, 4
    • activation composition and acute respiratory syndrome: 1, 2
    • acute infection and additional analysis: 1, 2, 3, 4
    • acute infection and local outbreak: 1, 2, 3, 4, 5
    • acute infection and local resource: 1
    • acute infection and long term short: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17
    • acute infection and low respiratory tract infection: 1, 2
    • acute infection and lumbar puncture: 1, 2, 3, 4, 5, 6, 7, 8
    • acute research and long term short: 1, 2
    • acute respiratory and additional analysis: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
    • acute respiratory and adjustment allow: 1
    • acute respiratory and local expertise: 1, 2
    • acute respiratory and local outbreak: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • acute respiratory and local resource: 1, 2, 3
    • acute respiratory and long term short: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • acute respiratory and low respiratory tract infection: 1, 2, 3
    • acute respiratory and lumbar puncture: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17
    • acute respiratory syndrome and additional analysis: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18
    • acute respiratory syndrome and local expertise: 1