Selected article for: "acute influenza and adenovirus infection"
Author: Hönemann, Mario; Lück, Christian; Maier, Melanie; Pietsch, Corinna; Dietze, Nadine; Berthold, Tom; Encalada, Marco Vinicio Narvaez; Grünewald, Thomas; Neumeister, Volker; Dalpke, Alexander; Liebert, Uwe Gerd
Title: Comprehensive evaluation of eight commercial SARS-CoV-2 IgG assays
  • Cord-id: d55uq2s9
  • Document date: 2021_3_22
    • ID: d55uq2s9
    Snippet: Sensitivity and specificity of serological assays are key parameters for the accurate estimation of SARS-CoV-2 sero-prevalence. The aim of this study was to compare eight readily available IgG antibody tests using a panel of well-defined serum samples of pre-pandemic and pandemic origin. A cross-reaction panel included samples of patients with recent infection with either of the endemic Coronaviruses 229E, NL63, HKU1, or OC43. Additionally, samples with high antibody levels against influenza vir
    Document: Sensitivity and specificity of serological assays are key parameters for the accurate estimation of SARS-CoV-2 sero-prevalence. The aim of this study was to compare eight readily available IgG antibody tests using a panel of well-defined serum samples of pre-pandemic and pandemic origin. A cross-reaction panel included samples of patients with recent infection with either of the endemic Coronaviruses 229E, NL63, HKU1, or OC43. Additionally, samples with high antibody levels against influenza virus, adenovirus, and during acute EBV infection were included. Previous infection with endemic coronaviruses caused a significant amount of cross-reactivity in two of the assays. In contrast, the confidence intervals for the assays of Abbott, DiaSorin, Euroimmun and Roche encompassed the value of 98% for samples with a previous endemic hCoV infection. For all assays, sensitivities were between 91.3 and 98.8%. Assay performance was independent of the usage of either nucleocapsid or spike proteins.

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