Author: Martin Bartas; Václav Brázda; Natália Bohálová; Alessio Cantara; Adriana Volná; Tereza Stachurová; Katerina Malachová; Eva B. Jagelská; Otília Porubiaková; Jirí Cerven; Petr Pecinka
Title: In-depth Bioinformatic Analyses of Human SARS-CoV-2, SARS-CoV, MERS-CoV, and Other Nidovirales Suggest Important Roles of Noncanonical Nucleic Acid Structures in Their Lifecycles Document date: 2020_4_11
ID: d3q0xel1_2
Snippet: In all prokaryotic and eukaryotic cells, as well as viruses, there have been found sequence motifs such as IR sequences forming cruciforms and hairpins or G-rich sequences that form G-quadruplexes Lavezzo et al., 2018; Bartas et al., 2019) . In the present research, we conducted a systematic and comprehensive bioinformatic study searching for the occurrence of IRs and putative quadruplex sites (PQSs) within the genomes of all known Nidovirales. T.....
Document: In all prokaryotic and eukaryotic cells, as well as viruses, there have been found sequence motifs such as IR sequences forming cruciforms and hairpins or G-rich sequences that form G-quadruplexes Lavezzo et al., 2018; Bartas et al., 2019) . In the present research, we conducted a systematic and comprehensive bioinformatic study searching for the occurrence of IRs and putative quadruplex sites (PQSs) within the genomes of all known Nidovirales. The aim was to find one or more potential druggable RNA targets to address the present COVID-19 threat (Figure 1) .
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