Author: Ahmed-Hassan, Hanaa; Sisson, Brianna; Shukla, Rajni Kant; Wijewantha, Yasasvi; Funderburg, Nicholas T.; Li, Zihai; Hayes, Don; Demberg, Thorsten; Liyanage, Namal P. M.
Title: Innate Immune Responses to Highly Pathogenic Coronaviruses and Other Significant Respiratory Viral Infections Cord-id: j2ot35lt Document date: 2020_8_18
ID: j2ot35lt
Snippet: The new pandemic virus SARS-CoV-2 emerged in China and spread around the world in <3 months, infecting millions of people, and causing countries to shut down public life and businesses. Nearly all nations were unprepared for this pandemic with healthcare systems stretched to their limits due to the lack of an effective vaccine and treatment. Infection with SARS-CoV-2 can lead to Coronavirus disease 2019 (COVID-19). COVID-19 is respiratory disease that can result in a cytokine storm with stark di
Document: The new pandemic virus SARS-CoV-2 emerged in China and spread around the world in <3 months, infecting millions of people, and causing countries to shut down public life and businesses. Nearly all nations were unprepared for this pandemic with healthcare systems stretched to their limits due to the lack of an effective vaccine and treatment. Infection with SARS-CoV-2 can lead to Coronavirus disease 2019 (COVID-19). COVID-19 is respiratory disease that can result in a cytokine storm with stark differences in morbidity and mortality between younger and older patient populations. Details regarding mechanisms of viral entry via the respiratory system and immune system correlates of protection or pathogenesis have not been fully elucidated. Here, we provide an overview of the innate immune responses in the lung to the coronaviruses MERS-CoV, SARS-CoV, and SARS-CoV-2. This review provides insight into key innate immune mechanisms that will aid in the development of therapeutics and preventive vaccines for SARS-CoV-2 infection.
Search related documents:
Co phrase search for related documents- accessory protein and acute respiratory: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- accessory protein and acute sars cov respiratory syndrome cov: 1, 2
- activation influx and acute ali lung injury: 1
- activation influx and acute ards respiratory distress syndrome: 1
- activation influx and acute respiratory: 1, 2
- activation neutrophil recruitment and acute ali lung injury: 1, 2, 3, 4
- activation neutrophil recruitment and acute ards respiratory distress syndrome: 1, 2, 3
- activation neutrophil recruitment and acute respiratory: 1, 2, 3, 4, 5, 6, 7, 8
- activation neutrophil recruitment and adaptive innate: 1
- acute ali lung injury and adaptive immune response: 1, 2
- acute ali lung injury and adaptive immune response innate: 1, 2
- acute ali lung injury and adaptive immunity: 1
- acute ali lung injury and adaptive innate: 1, 2, 3
- acute ali lung injury and adaptive innate immune cell: 1
- acute ards respiratory distress syndrome and adaptive immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- acute ards respiratory distress syndrome and adaptive immune response innate: 1, 2, 3, 4, 5, 6, 7
- acute ards respiratory distress syndrome and adaptive immunity: 1, 2, 3, 4, 5, 6, 7
- acute ards respiratory distress syndrome and adaptive innate: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22
- acute ards respiratory distress syndrome and adaptive innate immune cell: 1, 2
Co phrase search for related documents, hyperlinks ordered by date