Author: Korbinian Bösl; Aleksandr Ianevski; Thoa T. Than; Petter I. Andersen; Suvi Kuivanen; Mona Teppor; Eva Zusinaite; Uga Dumpis; Astra Vitkauskiene; Rebecca J. Cox; Hannimari Kallio-Kokko; Anders Bergqvist; Tanel Tenson; Valentyn Oksenych; Magnar Bjørås; Marit W. Anthonsen; David Shum; Mari Kaarbø; Olli Vapalahti; Marc P. Windisch; Giulio Superti-Furga; Berend Snijder; Denis Kainov; Richard K. Kandasamy
Title: Critical Nodes of Virus–Host Interaction Revealed Through an Integrated Network Analysis Document date: 2019_2_13
ID: ig6ul3u7_4
Snippet: We hypothesized that combining a meta-analysis of host-virus protein-protein interactions of multiple viruses and functional RNAi screens would provide novel insights for developing broad-spectrum antiviral strategies. For this, we assembled a host-virus protein-protein interactome of 5781 host-virus interactions (hereafter referred to as 'hvPPI') covering 183 viral proteins from 17 different viruses and 2381 host proteins. We performed extensive.....
Document: We hypothesized that combining a meta-analysis of host-virus protein-protein interactions of multiple viruses and functional RNAi screens would provide novel insights for developing broad-spectrum antiviral strategies. For this, we assembled a host-virus protein-protein interactome of 5781 host-virus interactions (hereafter referred to as 'hvPPI') covering 183 viral proteins from 17 different viruses and 2381 host proteins. We performed extensive bioinformatics and network analysis and integrated this dataset with genome-wide or druggable-genome RNAi screen data from published studies. This resulted in the assembly of critical nodes of viral evasion and identification of core cellular processes and druggable nodes that were verified by a drug re-purposing screen using broad-spectrum antivirals.
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