Author: Ye, Lilin; Chen, Xiangyu; Li, Ren; Pan, Zhiwei; Qian, Chunfeng; Yang, Yang; You, Renrong; Zhao, Jing; Gao, Leiqong; Li, Zhirong; Huang, Qizhao; Xu, Lifan; Tang, Jianfang; Tian, Qin; Yao, Wei; Hu, Li; Yan, Xiaofeng; Zhou, Xinyuan; Liu, Pinghuang; Wu, Yuzhang; Deng, Kai; Zhang, Zheng; Chen, Yaokai; Qian, Zhaohui
Title: Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor Cord-id: 9a2pyqrf Document date: 2020_4_11
ID: 9a2pyqrf
Snippet: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic of novel corona virus disease (COVID-19). To date, no prophylactic vaccines or approved therapeutic agents are available for preventing and treating this highly transmittable disease. Here we report two monoclonal antibodies (mAbs) cloned from memory B cells of patients recently recovered from COVID-19, and both mAbs specifically bind to the spike (S) protein of SARS-CoV-2, block the binding of receptor
Document: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic of novel corona virus disease (COVID-19). To date, no prophylactic vaccines or approved therapeutic agents are available for preventing and treating this highly transmittable disease. Here we report two monoclonal antibodies (mAbs) cloned from memory B cells of patients recently recovered from COVID-19, and both mAbs specifically bind to the spike (S) protein of SARS-CoV-2, block the binding of receptor binding domain (RBD) of SARS-CoV-2 to human angiotensin converting enzyme 2 (hACE2), and effectively neutralize S protein-pseudotyped virus infection. These human mAbs hold the promise for the prevention and treatment of the ongoing pandemic of COVID-19.
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