Selected article for: "activation macrophage hemophagocytic lymphohistiocytosis and macrophage activation syndrome"
Author: Klocperk, Adam; Parackova, Zuzana; Dissou, Jitka; Malcova, Hana; Pavlicek, Petr; Vymazal, Tomas; Dolezalova, Pavla; Sediva, Anna
Title: Case Report: Systemic Inflammatory Response and Fast Recovery in a Pediatric Patient With COVID-19
  • Cord-id: di3lioxb
  • Document date: 2020_7_3
    • ID: di3lioxb
    Snippet: We report a case of an 8-year-old girl who underwent a SARS-CoV-2 infection manifesting with atypical symptoms spearheaded by abdominal discomfort and systemic inflammation and partially mimicking hemophagocytic lymphohistiocytosis (HLH) or macrophage activation syndrome (MAS), which however did not fulfill the HLH/MAS diagnostic criteria. In this case of what has since been described as Pediatric Inflammatory Multisystem Syndrome Temporally associated with SARS-COV-2 (PIMS-TS) we documented exc
    Document: We report a case of an 8-year-old girl who underwent a SARS-CoV-2 infection manifesting with atypical symptoms spearheaded by abdominal discomfort and systemic inflammation and partially mimicking hemophagocytic lymphohistiocytosis (HLH) or macrophage activation syndrome (MAS), which however did not fulfill the HLH/MAS diagnostic criteria. In this case of what has since been described as Pediatric Inflammatory Multisystem Syndrome Temporally associated with SARS-COV-2 (PIMS-TS) we documented excellent clinical response to immunosuppression with systemic corticosteroids and intravenous immunoglobulins. We show a detailed longitudinal development of neutrophil immunophenotype which suggests activation and engagement of neutrophils during PIMS-TS with compensatory contraction of the response and contra-regulation of neutrophil phenotype during recovery.

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