Author: Zhang, Jason Z.; Yeh, Hsien-Wei; Walls, Alexandra C.; Wicky, Basile I.M.; Sprouse, Kaiti; VanBlargan, Laura A.; Treger, Rebecca; Quijano-Rubio, Alfredo; Pham, Minh N.; Kraft, John C.; Haydon, Ian C.; Yang, Wei; DeWitt, Michelle; Chow, Cameron; Carter, Lauren; Wener, Mark H.; Stewart, Lance; Veesler, David; Diamond, Michael S.; Baker, David
Title: Detection of antibodies neutralizing historical and emerging SARS-CoV-2 strains using a thermodynamically coupled de novo biosensor system Cord-id: 9ap2odoy Document date: 2021_6_22
ID: 9ap2odoy
Snippet: With global vaccination efforts against SARS-CoV-2 underway, there is a need for rapid quantification methods for neutralizing antibodies elicited by vaccination and characterization of their strain dependence. Here, we describe a designed protein biosensor that enables sensitive and rapid detection of neutralizing antibodies against wild type and variant SARS-CoV-2 in serum samples. More generally, our thermodynamic coupling approach can better distinguish sample to sample differences in analyt
Document: With global vaccination efforts against SARS-CoV-2 underway, there is a need for rapid quantification methods for neutralizing antibodies elicited by vaccination and characterization of their strain dependence. Here, we describe a designed protein biosensor that enables sensitive and rapid detection of neutralizing antibodies against wild type and variant SARS-CoV-2 in serum samples. More generally, our thermodynamic coupling approach can better distinguish sample to sample differences in analyte binding affinity and abundance than traditional competition based assays.
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