Increased Neurite Orientation-Dispersion and Density in the TgCRND8 Mouse Model of Amyloidosis: Inverse Relation with Functional Connectome Clustering and Modulation by Interleukin-6

Luis M. Colon-Perez; Kristen R. Ibanez; Mallory Suarez; Kristin Torroella; Kelly Acuna; Edward Ofori; Yona Levites; David E. Vaillancourt; Todd E. Golde; Paramita Chakrabarty; Marcelo Febo

A T2-weighted Turbo Rapid Acquisition with Refocused Echoes (RARE) sequence was used for acquiring anatomical scans with the following parameters: echo time (TE) = 41 ms, repetition time (TR) = 4 seconds, RARE factor = 16, number of averages = 12, field of view (FOV) 15 mm x 11 mm and 0.7 mm thick slice, and 256 x 256 x 17 coronal (axial) slices covering the entire brain from the rostral-most extent of the prefrontal cortical region and caudally to the upper brainstem/cerebellum. Functional images were collected using a single-shot spin-echo echo planar imaging (EPI) sequence with the following parameters: TE = 15 ms, TR = 2 seconds, 180 repetitions, 15 x 11 mm in plane, 14 slices with 0.9 mm thickness per slice, data matrix = 64 x 48. No stimuli were presented during functional scanning and respiratory rates, isoflurane concentration, body temperature, lighting and room conditions were kept constant across subjects.