The phylogenetic approach for viral infectious disease evolution and epidemiology: an updating review.

Ciccozzi, Massimo; Lai, Alessia; Zehender, Gianguglielmo; Borsetti, Alessandra; Cella, Eleonora; Ciotti, Marco; Sagnelli, Evangelista; Sagnelli, Caterina; Angeletti, Silvia

In the last decade, phylogenetic approach is recurrent in molecular evolutionary analysis. On May 12th , 2019, about 2.296.213 papers are found, but typing "phylogeny" or "epidemiology AND phylogeny" only 199.804 and 20.133 are retrieved, respectively. Molecular epidemiology in infectious diseases is widely used to define the source of infection as so as the ancestral relationships of individuals sampled from a population. Coalescent theory and phylogeographic analysis have had scientific application in several, recent pandemic events, and nosocomial outbreaks. Hepatitis viruses and Immunodeficiency Virus (HIV) have been largely studied. Phylogenetic analysis has been recently applied on Polyomaviruses so as in the more recent outbreaks due to different Arboviruses type as Zika and Chikungunya viruses discovering the source of infection and the geographic spread. Data on sequences isolated by the microorganism are essential to apply the phylogenetic tools and research in the field of infectious disease phylodinamics is growing up. There is the need to apply molecular phylogenetic and evolutionary methods in areas out of infectious diseases, as translational genomics and personalized medicine. Lastly the application of these tools in vaccine strategy so as in antibiotic and antiviral researchers are encouraged. This article is protected by copyright. All rights reserved.