Author: Moreira-Soto, Andres; Arguedas, Mauricio; Brenes, Hebleen; Buján, Willem; Corrales-Aguilar, Eugenia; DÃaz, Cecilia; Echeverri, Ann; Flores-DÃaz, Marietta; Gómez, Aarón; Hernández, Andrés; Herrera, MarÃa; León, Guillermo; Macaya, Román; Kühne, Arne; Molina-Mora, José Arturo; Mora, Javier; Sanabria, Alfredo; Sánchez, Andrés; Sánchez, Laura; Segura, Ãlvaro; Segura, Eduardo; Solano, Daniela; Soto, Claudio; Stynoski, Jennifer L.; Vargas, Mariángela; Villalta, Mauren; Reusken, Chantal B. E. M.; Drosten, Christian; Gutiérrez, José MarÃa; Alape-Girón, Alberto; Drexler, Jan Felix
Title: High Efficacy of Therapeutic Equine Hyperimmune Antibodies Against SARS-CoV-2 Variants of Concern Cord-id: qfh5netm Document date: 2021_9_6
ID: qfh5netm
Snippet: SARS-CoV-2 variants of concern show reduced neutralization by vaccine-induced and therapeutic monoclonal antibodies; therefore, treatment alternatives are needed. We tested therapeutic equine polyclonal antibodies (pAbs) that are being assessed in clinical trials in Costa Rica against five globally circulating variants of concern: alpha, beta, epsilon, gamma and delta, using plaque reduction neutralization assays. We show that equine pAbs efficiently neutralize the variants of concern, with inhi
Document: SARS-CoV-2 variants of concern show reduced neutralization by vaccine-induced and therapeutic monoclonal antibodies; therefore, treatment alternatives are needed. We tested therapeutic equine polyclonal antibodies (pAbs) that are being assessed in clinical trials in Costa Rica against five globally circulating variants of concern: alpha, beta, epsilon, gamma and delta, using plaque reduction neutralization assays. We show that equine pAbs efficiently neutralize the variants of concern, with inhibitory concentrations in the range of 0.146–1.078 μg/mL, which correspond to extremely low concentrations when compared to pAbs doses used in clinical trials. Equine pAbs are an effective, broad coverage, low-cost and a scalable COVID-19 treatment.
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