Author: Luis M. Colon-Perez; Kristen R. Ibanez; Mallory Suarez; Kristin Torroella; Kelly Acuna; Edward Ofori; Yona Levites; David E. Vaillancourt; Todd E. Golde; Paramita Chakrabarty; Marcelo Febo
Title: Increased Neurite Orientation-Dispersion and Density in the TgCRND8 Mouse Model of Amyloidosis: Inverse Relation with Functional Connectome Clustering and Modulation by Interleukin-6 Document date: 2019_2_27
ID: hyeygk64_60
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/562348 doi: bioRxiv preprint hippocampus: main effect strain F1,43 = 5.8 p = 0.01). The effects of IL6 were not widespread in the assessed structures and were also strain/tissue type dependent. Thus, in the cerebral peduncle (WM) IL6 reduced ODI only in Tg mice (treatment x strain interaction F1,43 = 12.4 p = 0.001 and main effect .....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/562348 doi: bioRxiv preprint hippocampus: main effect strain F1,43 = 5.8 p = 0.01). The effects of IL6 were not widespread in the assessed structures and were also strain/tissue type dependent. Thus, in the cerebral peduncle (WM) IL6 reduced ODI only in Tg mice (treatment x strain interaction F1,43 = 12.4 p = 0.001 and main effect treatment F1,43 = 17.0 p = 0.0002), whereas in the hippocampus (grey matter) IL6 increased ODI only in nTg mice (main effect treatment F1,43 = 6.1 p = 0.02).
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