Author: Korbinian Bösl; Aleksandr Ianevski; Thoa T. Than; Petter I. Andersen; Suvi Kuivanen; Mona Teppor; Eva Zusinaite; Uga Dumpis; Astra Vitkauskiene; Rebecca J. Cox; Hannimari Kallio-Kokko; Anders Bergqvist; Tanel Tenson; Valentyn Oksenych; Magnar Bjørås; Marit W. Anthonsen; David Shum; Mari Kaarbø; Olli Vapalahti; Marc P. Windisch; Giulio Superti-Furga; Berend Snijder; Denis Kainov; Richard K. Kandasamy
Title: Critical Nodes of Virus–Host Interaction Revealed Through an Integrated Network Analysis Document date: 2019_2_13
ID: ig6ul3u7_89
Snippet: In particular our analysis of the hvPPI network revealed that all the viruses have evolved to target proteins that are central and have strong control over the human interactome. Host proteins targeted by viruses contain a high proportion of intrinsically disordered regions. We identified the core cellular processes and associated proteins that are targeted by all viruses. Detailed comparative analysis of the subcellular localization of the host .....
Document: In particular our analysis of the hvPPI network revealed that all the viruses have evolved to target proteins that are central and have strong control over the human interactome. Host proteins targeted by viruses contain a high proportion of intrinsically disordered regions. We identified the core cellular processes and associated proteins that are targeted by all viruses. Detailed comparative analysis of the subcellular localization of the host proteins showed commonality and specificity both between viral proteins from different strains of the same virus; and between viruses. Integrating hvPPI with functional RNAi screens showed that a large portion of the hvPPI are host factors of one or more virus. hvPPI data-based drug re-purposing screen identified novel activities for various broad-spectrum antivirals against HMPV and HCV.
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