Author: Korbinian Bösl; Aleksandr Ianevski; Thoa T. Than; Petter I. Andersen; Suvi Kuivanen; Mona Teppor; Eva Zusinaite; Uga Dumpis; Astra Vitkauskiene; Rebecca J. Cox; Hannimari Kallio-Kokko; Anders Bergqvist; Tanel Tenson; Valentyn Oksenych; Magnar Bjørås; Marit W. Anthonsen; David Shum; Mari Kaarbø; Olli Vapalahti; Marc P. Windisch; Giulio Superti-Furga; Berend Snijder; Denis Kainov; Richard K. Kandasamy
Title: Critical Nodes of Virus–Host Interaction Revealed Through an Integrated Network Analysis Document date: 2019_2_13
ID: ig6ul3u7_89
Snippet: In particular our analysis of the hvPPI network revealed that all the viruses have evolved to target proteins that are central and have strong control over the human interactome. Host proteins targeted by viruses contain a high proportion of intrinsically disordered regions. We identified the core cellular processes and associated proteins that are targeted by all viruses. Detailed comparative analysis of the subcellular localization of the host .....
Document: In particular our analysis of the hvPPI network revealed that all the viruses have evolved to target proteins that are central and have strong control over the human interactome. Host proteins targeted by viruses contain a high proportion of intrinsically disordered regions. We identified the core cellular processes and associated proteins that are targeted by all viruses. Detailed comparative analysis of the subcellular localization of the host proteins showed commonality and specificity both between viral proteins from different strains of the same virus; and between viruses. Integrating hvPPI with functional RNAi screens showed that a large portion of the hvPPI are host factors of one or more virus. hvPPI data-based drug re-purposing screen identified novel activities for various broad-spectrum antivirals against HMPV and HCV.
Search related documents:
Co phrase search for related documents- associate protein and host protein: 1, 2, 3, 4, 5, 6, 7, 8, 9
- broad spectrum and cellular process: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- broad spectrum and comparative analysis: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
- broad spectrum and core cellular process: 1, 2
- broad spectrum and different strain: 1
- broad spectrum and drug purpose: 1
- broad spectrum and high proportion: 1, 2, 3, 4
- broad spectrum and host factor: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24
- broad spectrum and host protein: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- broad spectrum and human interactome: 1
- broad spectrum antiviral and cellular process: 1, 2, 3, 4, 5, 6, 7
- broad spectrum antiviral and comparative analysis: 1
- broad spectrum antiviral and core cellular process: 1, 2
- broad spectrum antiviral and different strain: 1
- broad spectrum antiviral and host factor: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
- broad spectrum antiviral and host protein: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23
- broad spectrum antiviral and human interactome: 1
- cellular process and core cellular process: 1, 2
- cellular process and host factor: 1
Co phrase search for related documents, hyperlinks ordered by date