Selected article for: "cross scale Î reproductive number and mutant reproductive number"
Author: Sebastian J. Schreiber; Ruian Ke; Claude Loverdo; Miran Park; Priyanna Ahsan; James O. Lloyd-Smith
Title: Cross-scale dynamics and the evolutionary emergence of infectious diseases
  • Document date: 2016_7_29
    • ID: hain3be0_41
    Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/066688 doi: bioRxiv preprint sharply with bottleneck size (Fig 4B and Appendix) . Because a mutant reproductive number R m greater than one requires a between-host selective advantage (τ > 0) for a long-term infection, the cross-scale reproductive number α is less than one only if there is a within-host selective disadvantage (s .....
    Document: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/066688 doi: bioRxiv preprint sharply with bottleneck size (Fig 4B and Appendix) . Because a mutant reproductive number R m greater than one requires a between-host selective advantage (τ > 0) for a long-term infection, the cross-scale reproductive number α is less than one only if there is a within-host selective disadvantage (s < 0) so that mixed infections tend to be taken over by the wild-type. Consequently, the mutant virus can start an epidemic only when a host is infected with an initial All rights reserved. No reuse allowed without permission.

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