Author: Sujin Lee; Minh Trang Nguyen; Michael G. Currier; Joe B. Jenkins; Elizabeth A. Strobert; Adriana E. Kajon; Ranjna Madan-Lala; Yury A. Bochkov; James E. Gern; Krishnendu Roy; Xiaoyan Lu; Dean D. Erdman; Paul Spearman; Martin L. Moore
Title: 50-valent inactivated rhinovirus vaccine is broadly immunogenic in rhesus macaques Document date: 2016_5_17
ID: 2eh0bhee_6
Snippet: In order to increase vaccine valency, we chose rhesus macaques (RMs) and a 1.0 ml i.m. Table 3 ). The 25-valent 114 vaccine induced nAb to 96% (RM A) and 100% (RM B) of input viruses following the prime 115 vaccination (Fig. 4a) . The 50-valent vaccine induced nAb to 90% (RM C) and 82% (RM D) of 116 input viruses following the prime vaccination (Fig. 4c) . The breadth of nAb following prime 117 vaccination in RM was superior to what we observed i.....
Document: In order to increase vaccine valency, we chose rhesus macaques (RMs) and a 1.0 ml i.m. Table 3 ). The 25-valent 114 vaccine induced nAb to 96% (RM A) and 100% (RM B) of input viruses following the prime 115 vaccination (Fig. 4a) . The 50-valent vaccine induced nAb to 90% (RM C) and 82% (RM D) of 116 input viruses following the prime vaccination (Fig. 4c) . The breadth of nAb following prime 117 vaccination in RM was superior to what we observed in mice, which may have been due to 118 animal species differences and/or higher inactivated-TCID 50 input titers in the RM vaccines.
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