Author: Luis M. Colon-Perez; Kristen R. Ibanez; Mallory Suarez; Kristin Torroella; Kelly Acuna; Edward Ofori; Yona Levites; David E. Vaillancourt; Todd E. Golde; Paramita Chakrabarty; Marcelo Febo
Title: Increased Neurite Orientation-Dispersion and Density in the TgCRND8 Mouse Model of Amyloidosis: Inverse Relation with Functional Connectome Clustering and Modulation by Interleukin-6 Document date: 2019_2_27
ID: hyeygk64_71
Snippet: Using an Alzheimer's disease mouse model, we carried out high field dMRI to investigate how amyloidosis with inflammatory conditioning induced by IL6 alters DTI, FW and NODDI metrics (summarized in Figure 10 ). Our data indicate that Aβ and IL6 differentially alter tissue microstructure measured by dMRI (e.g., fractional anisotropy, mean, axial and radial diffusivities, neurite density and orientation dispersion). Aβ and IL6 had diametrically d.....
Document: Using an Alzheimer's disease mouse model, we carried out high field dMRI to investigate how amyloidosis with inflammatory conditioning induced by IL6 alters DTI, FW and NODDI metrics (summarized in Figure 10 ). Our data indicate that Aβ and IL6 differentially alter tissue microstructure measured by dMRI (e.g., fractional anisotropy, mean, axial and radial diffusivities, neurite density and orientation dispersion). Aβ and IL6 had diametrically distinct effects on FA and AD whereas their effects on free water and NODDI metrics were similar in directionality.
Search related documents:
Co phrase search for related documents- disease mouse and inflammatory conditioning: 1
- disease mouse model and high field: 1
- disease mouse model and inflammatory conditioning: 1
- free water and high field: 1
- free water and inflammatory conditioning: 1
- free water and neurite density: 1, 2, 3, 4, 5
- free water and NODDI metric: 1
- free water and orientation dispersion: 1, 2, 3, 4, 5, 6
- free water and orientation dispersion neurite density: 1, 2, 3, 4
- free water and tissue microstructure: 1, 2, 3
- high field and neurite density: 1
- high field and orientation dispersion: 1
- high field and orientation dispersion neurite density: 1
- neurite density and NODDI metric: 1
- neurite density and orientation dispersion: 1, 2, 3, 4, 5, 6, 7
- neurite density and orientation dispersion neurite density: 1, 2, 3, 4, 5
- NODDI metric and orientation dispersion: 1
- orientation dispersion and tissue microstructure: 1
Co phrase search for related documents, hyperlinks ordered by date