Selected article for: "brain network and functional brain network"
Author: Luis M. Colon-Perez; Kristen R. Ibanez; Mallory Suarez; Kristin Torroella; Kelly Acuna; Edward Ofori; Yona Levites; David E. Vaillancourt; Todd E. Golde; Paramita Chakrabarty; Marcelo Febo
Title: Increased Neurite Orientation-Dispersion and Density in the TgCRND8 Mouse Model of Amyloidosis: Inverse Relation with Functional Connectome Clustering and Modulation by Interleukin-6
  • Document date: 2019_2_27
    • ID: hyeygk64_90
    Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/562348 doi: bioRxiv preprint Finally, we observed an inverse linear relationship between NDI, ODI in WM and hippocampus and the functional connectomic clustering coefficient. High NDI and ODI was negatively correlated with low clustering, which suggests that increasing the density and orientation dispersion of neurites may diminish.....
    Document: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/562348 doi: bioRxiv preprint Finally, we observed an inverse linear relationship between NDI, ODI in WM and hippocampus and the functional connectomic clustering coefficient. High NDI and ODI was negatively correlated with low clustering, which suggests that increasing the density and orientation dispersion of neurites may diminish functional network organization in the brain. Implied in this relationship is that in addition to capturing neuronal fiber organization, NODDI metrics somehow measures components of microstructure that may describe or relate to neuronal activity and how neuronal communication is organized in the brain. Recently it was reported that high neurite density in auditory/temporal cortex in humans was associated with a decrease latency (faster processing) of neurophysiological processing of speech (Ocklenburg et al., 2018) .

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