Individualized System for Augmenting Ventilator Efficacy (iSAVE): A Rapidly deployable system to expand ventilator capacity

Shriya Srinivasan; Khalil Ramadi; Franceso Vicario; Declan Gwynne; Alison Hayward; Robert Langer; Joseph Frassica; Rebecca Baron; Giovanni Traverso

In addition to the components described and demonstrated here, CO2 sensors could be easily incorporated into the setup for personalized monitoring of inspired and expired air in each patient circuit. A whistle ring could be added to the pressure release valve to provide an additional auditory alarm when a change occurs in the system causing high pressure in one segment (See Supplemental Figure 3 ). Future iterations could incorporate closedloop control, directly modulating flow based on flow meter readings and valves to allow for independent control of RR and FiO2 in each patient circuit. Although, this system, as described, permits individualized minute ventilation through alteration in tidal volume for each patient. Finally, the capacity to derive plateau pressures can be built into the circuit. In theory, this system can accommodate more than two patients, although this may present significant practical challenges. Please see Supplemental Note 1 for more details.