Author: Easton, Donna M.; Nijnik, Anastasia; Mayer, Matthew L.; Hancock, Robert E.W.
Title: Potential of immunomodulatory host defense peptides as novel anti-infectives Cord-id: dnxkzi3j Document date: 2009_8_14
ID: dnxkzi3j
Snippet: A fundamentally new strategy for the treatment of infectious disease is the modulation of host immune responses to enhance clearance of infectious agents and reduce tissue damage due to inflammation. Antimicrobial host defense peptides have been investigated for their potential as a new class of antimicrobial drugs. Recently their immunomodulatory activities have begun to be appreciated. Modulation of innate immunity by synthetic variants of host defense peptides, called innate defense regulator
Document: A fundamentally new strategy for the treatment of infectious disease is the modulation of host immune responses to enhance clearance of infectious agents and reduce tissue damage due to inflammation. Antimicrobial host defense peptides have been investigated for their potential as a new class of antimicrobial drugs. Recently their immunomodulatory activities have begun to be appreciated. Modulation of innate immunity by synthetic variants of host defense peptides, called innate defense regulators (IDRs), is protective without direct antimicrobial action. We discuss the potential and current limitations in exploiting the immunomodulatory activity of IDRs as a novel anti-infective pathway. IDRs show significant promise and current research is uncovering mechanistic information that will aid in the future development of IDRs for clinical use.
Search related documents:
Co phrase search for related documents- action mechanism and adaptive immunity: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- action mechanism and adjuvant activity: 1, 2, 3
- action mechanism and adoptive transfer: 1
- activation dc maturation and adaptive immunity: 1, 2, 3
- activator kinase signal transducer and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9
- activator kinase signal transducer and adaptive immunity: 1
- acute respiratory syndrome and adaptive immunity: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- acute respiratory syndrome and adjuvant activity: 1, 2
- acute respiratory syndrome and adjuvant chemotherapy: 1, 2
- acute respiratory syndrome and adjuvant formulation: 1, 2, 3
- acute respiratory syndrome and adoptive transfer: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- adaptive immunity and adjuvant activity: 1, 2, 3
- adaptive immunity and adoptive transfer: 1, 2, 3, 4
- adaptive immunity and live bacteria: 1
- adjuvant activity and adoptive transfer: 1
- adjuvant formulation and adoptive transfer: 1
Co phrase search for related documents, hyperlinks ordered by date