Individualized System for Augmenting Ventilator Efficacy (iSAVE): A Rapidly deployable system to expand ventilator capacity

Shriya Srinivasan; Khalil Ramadi; Franceso Vicario; Declan Gwynne; Alison Hayward; Robert Langer; Joseph Frassica; Rebecca Baron; Giovanni Traverso

Data from these sensors can be visualized on separate patient monitors or on the ventilator. During the initial set up, the respiratory rate, PEEP, FiO2 and inspiration:expiration time, and the sum of the VT for both patients is set on the ventilator. Then, the flow control valves can be titrated to provide the desired volume to each patient. The exhaled volume and minute ventilation alarms on the ventilator are set based on the sum of the exhaled tidal volumes from both patients. This alarm will enable the ventilator to notify clinicians in the case of any sudden changes in the volume delivered to each patient (e.g., shunt, occlusion or, disconnection of the endotracheal tube). PEEP valves in each patient's circuit should also be set to the maximum pressure allowable for that patient. The copyright holder for this preprint (which was not peer-reviewed) is the . closed-circuit (dual limb) ventilator employing 2 channels connected to a test lung apparatus for benchtop validation. The Philips NM3 respiratory monitor is used to monitor the pressure, flow, and CO2 in each patient circuit. C) Circuit diagram to implement the iSAVE on closed-circuit ventilators. D) Variable tidal volumes are delivered through the system. E) Left: Simulation of decreased compliance in one lung (blue) and (Right) increased compliance in one lung (black) G) Simulation of increased resistance in one lung (blue) and (Right) decreased resistance in one lung (black).