Author: Rajanish Giri; Taniya Bhardwaj; Meenakshi Shegane; Bhuvaneshwari R. Gehi; Prateek Kumar; Kundlik Gadhave
Title: Dark Proteome of Newly Emerged SARS-CoV-2 in Comparison with Human and Bat Coronaviruses Document date: 2020_3_14
ID: n7ylgqfu_108
Snippet: The emergence of new viruses and associated deaths around the globe represent one of the major concerns of modern times. Despite its pandemic nature, there is very little information available in the public domain regarding the structures and functions of SARS-CoV-2 proteins. Based on its similarity with Human SARS CoV and Bat CoV, the published reports have suggested the functions of SARS-CoV-2 proteins. In this study, we utilized information av.....
Document: The emergence of new viruses and associated deaths around the globe represent one of the major concerns of modern times. Despite its pandemic nature, there is very little information available in the public domain regarding the structures and functions of SARS-CoV-2 proteins. Based on its similarity with Human SARS CoV and Bat CoV, the published reports have suggested the functions of SARS-CoV-2 proteins. In this study, we utilized information available on SARS-CoV-2 genome and translated proteome from GenBank, and carried out a comprehensive computational analysis of the prevalence of the intrinsic disorder in SARS-CoV-2 proteins. Additionally, a comparison was also made with proteins from close relatives of SARS-CoV-2 from the same group of beta coronaviruses, Human SARS CoV and Bat CoV. Our analysis revealed that in these three CoVs, the N proteins are highly disordered, possessing the PPID values of more than 60%. These viruses also have several moderately disordered proteins, such as Nsp8, Orf6, and Orf9b. Although other proteins have shown lower disorder content, almost all of them contain at least some IDPRs, and all CoV proteins author/funder. All rights reserved. No reuse allowed without permission.
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