Original Article Highlights From This Issue

Patients with chronic obstructive pulmonary disease (COPD) and asthma were more likely to reach the composite endpoint (needing invasive ventilation, admission to intensive care unit, or death within 30 days after hospitalization) compared with those without, after adjusting for age, sex, and other systemic comorbidities. Screening and appropriate triage of patients at high risk of being unable to complete video visits or return for follow-up testing is needed to ensure that telemedicine does not exacerbate existing health disparities in allergy/immunology care.Cluster Analysis of Inflammatory Biomarker Expression in the International Severe Asthma Registry Denton et al 2680 What is already known about this topic? Understanding more about distinct patterns of underlying inflammatory pathway activation in individual severe asthma patients allows clinicians to tailor targeted severe asthma therapies such as monoclonal biologics, furthering precision medicine for severe asthma.Factors Associated with Frequent Exacerbations in the UK Severe Asthma Registry Yang et al 2691 What is already known about this topic? Risk factors for frequent asthma exacerbations include high T2 biomarkers (fractional exhaled nitric oxide and blood eosinophil count) and asthma-associated conditions (obesity and rhinitis) in clinical trial patients or asthma populations with mixed disease severity.