Author: Rajanish Giri; Taniya Bhardwaj; Meenakshi Shegane; Bhuvaneshwari R. Gehi; Prateek Kumar; Kundlik Gadhave
Title: Dark Proteome of Newly Emerged SARS-CoV-2 in Comparison with Human and Bat Coronaviruses Document date: 2020_3_14
ID: n7ylgqfu_21
Snippet: Envelope (E) protein is a small, multifunctional inner membrane protein that plays an important role in the assembly and morphogenesis of virions in the cell [59] [60] [61] . E protein consists of two ectodomains associated with N-and C-terminal regions, and a transmembrane domain. It homo-oligomerize to form pentameric membrane destabilizing transmembrane (TM) hairpins to form a pore necessary for its ion channel activity [62] . Figure 4A shows .....
Document: Envelope (E) protein is a small, multifunctional inner membrane protein that plays an important role in the assembly and morphogenesis of virions in the cell [59] [60] [61] . E protein consists of two ectodomains associated with N-and C-terminal regions, and a transmembrane domain. It homo-oligomerize to form pentameric membrane destabilizing transmembrane (TM) hairpins to form a pore necessary for its ion channel activity [62] . Figure 4A shows the NMR-structure (PDB ID: 2MM4) of Human SARS envelope glycoprotein of 8-65 residues [63] .
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