A comparison study of SARS-CoV-2 IgG antibody between male and female COVID-19 patients: a possible reason underlying different outcome between gender.

Fanfan Zeng; Chan Dai; Pengcheng Cai; Jinbiao Wang; Lei Xu; Jianyu Li; Guoyun Hu; Lin Wang

Previous study reported a high severe rate and death rate in male patients relative to female patients [2] . However, the possible reason underlying was not referred. Here we reported that the production and dynamic of IgG antibody were different between male and female patients. In the early phase of the disease, the IgG antibody presented a stronger production in female patients. In the severe status, contrast with the male, SARS-CoV-2 IgG antibody in female tended to enrich in the high levels. The above two phenomena may be good reasons to explain the different outcomes between male and female COVID-19 patients. However, the exact mechanism contributing to this difference remains elusive and needs further investigation. At present, convalescent plasma was considered as a potential therapy for COVID-19 and now has been used in sever and critical patients in clinical [9] . Our study proposed that convalescent plasma should be used in advance especially for female patient with low IgG antibody for a long time to prevent the disease from progressing to severe and critical status, if the convalescent plasma is available. In addition, our study also supported that monitoring the SARS-CoV-2 antibody for routine examination maybe an efficient way to predict the progression of COVID-19 patients.