Author: Rajanish Giri; Taniya Bhardwaj; Meenakshi Shegane; Bhuvaneshwari R. Gehi; Prateek Kumar; Kundlik Gadhave
Title: Dark Proteome of Newly Emerged SARS-CoV-2 in Comparison with Human and Bat Coronaviruses Document date: 2020_3_14
ID: n7ylgqfu_60
Snippet: In coronaviruses, due to ribosomal leakage during translation, two-third of the RNA genome is processed into two polyproteins: (i) Replicase polyprotein 1a and (ii) Replicase polyprotein 1ab. Both contain non-structural proteins (Nsp1-10) in addition to different proteins required for viral replication and pathogenesis. Replicase polyprotein 1a contains an additional Nsp11 protein of 13 amino acids, the function of which is not investigated yet. .....
Document: In coronaviruses, due to ribosomal leakage during translation, two-third of the RNA genome is processed into two polyproteins: (i) Replicase polyprotein 1a and (ii) Replicase polyprotein 1ab. Both contain non-structural proteins (Nsp1-10) in addition to different proteins required for viral replication and pathogenesis. Replicase polyprotein 1a contains an additional Nsp11 protein of 13 amino acids, the function of which is not investigated yet. The longer replicase polyprotein 1ab of 7073 amino acids accommodates five other non-structural proteins (Nsp12-16) [122] . These proteins assist in ER membrane-induced vesicle formation, which acts as sites for replication and transcription. In addition to this, non-structural proteins work as proteases, helicases, and mRNA capping and methylation enzymes, crucial for virus survival and replication inside host cells [122, 123] . author/funder. All rights reserved. No reuse allowed without permission.
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