Selected article for: "helicase activity and unwinding activity"
Author: Rajanish Giri; Taniya Bhardwaj; Meenakshi Shegane; Bhuvaneshwari R. Gehi; Prateek Kumar; Kundlik Gadhave
Title: Dark Proteome of Newly Emerged SARS-CoV-2 in Comparison with Human and Bat Coronaviruses
  • Document date: 2020_3_14
    • ID: n7ylgqfu_97
    Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.13.990598 doi: bioRxiv preprint Non-structural protein 13 (Nsp13). Nsp13 functions as a viral helicase and unwinds dsDNA/dsRNA in 5' to 3' direction [152] . Recombinant viral helicase expressed in E.coli Rosetta 2 strain was reported to unwind ~280 bp per second [152] . Figure 30D represents a 2.8 Ã… X-ray crystal structure of Human SARS .....
    Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.13.990598 doi: bioRxiv preprint Non-structural protein 13 (Nsp13). Nsp13 functions as a viral helicase and unwinds dsDNA/dsRNA in 5' to 3' direction [152] . Recombinant viral helicase expressed in E.coli Rosetta 2 strain was reported to unwind ~280 bp per second [152] . Figure 30D represents a 2.8 Ã… X-ray crystal structure of Human SARS Nsp13 (PDB ID: 6JYT) [153] . This helicase contains a 19-20 loop on 1A domain, which is primarily responsible for its unwinding activity. Furthermore, the study revealed an important interaction of Nsp12 with Nsp13 that further enhances its helicase activity [153] .

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