Is chronic obstructive pulmonary disease an independent predictor for adverse outcomes in coronavirus disease 2019 patients?

Xiao, W-W; Xu, J; Shi, L; Wang, Y-D; Yang, H-Y

OBJECTIVE This study aimed to investigate whether pre-existing chronic obstructive pulmonary disease (COPD) was an independent predictor for adverse outcomes in coronavirus disease 2019 (COVID-19) patients. MATERIALS AND METHODS We searched electronic databases, including PubMed, Web of Science, EMBASE, and Chinese National Knowledge Infrastructure (CNKI) to screen for eligible articles. A quantitative meta-analysis was performed on the basis of adjusted effect estimates. RESULTS We observed that COPD was significantly associated with an increased risk of adverse outcomes in COVID-19 patients, which is based on 18 studies with 26,075 cases reporting adjusted effect estimates (pooled effect = 1.53, 95% confidence interval (CI): 1.29-1.8; I2 = 35.4%, random-effects model). CONCLUSIONS We found that pre-existing COPD was an independent risk factor for predicting the adverse outcomes in COVID-19 patients.