Author: Thachil, Jecko
Title: Forum article: The protective rather than prothrombotic fibrinogen in COVIDâ€19 and other inflammatory states Cord-id: r644rxe3 Document date: 2020_6_3
ID: r644rxe3
Snippet: Hypercoagulability has been recognised as a common complication of COVIDâ€19. Exact mechanisms for this extreme coagulation activation have not yet been elucidated. However, one of the consistent laboratory finding is the increase in fibrinogen, in some cases, marked elevation. High circulating levels of fibrinogen have been linked to thrombosis for years and for this reason, hyperâ€fibrinogenemia is considered one of the mechanisms for COVIDâ€19 coagulopathy. In this forum article, instead o
Document: Hypercoagulability has been recognised as a common complication of COVIDâ€19. Exact mechanisms for this extreme coagulation activation have not yet been elucidated. However, one of the consistent laboratory finding is the increase in fibrinogen, in some cases, marked elevation. High circulating levels of fibrinogen have been linked to thrombosis for years and for this reason, hyperâ€fibrinogenemia is considered one of the mechanisms for COVIDâ€19 coagulopathy. In this forum article, instead of the prothrombotic role, a protective function for fibrinogen is discussed. Fibrinogen, like the other wellâ€known acute phase reactants, is increased in COVIDâ€19 possibly to protect the host.
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