Author: Pearson, Claire F; Jeffery, Rebecca; Thornton, Emily E
Title: Mucosal immune responses in COVID19 - a living review Cord-id: 8u6qzme8 Document date: 2021_1_25
ID: 8u6qzme8
Snippet: COVID-19 was initially characterized as a disease primarily of the lungs, but it is becoming increasingly clear that the SARS-CoV2 virus is able to infect many organs and cause a broad pathological response. The primary infection site is likely to be a mucosal surface, mainly the lungs or the intestine, where epithelial cells can be infected with virus. Although it is clear that virus within the lungs can cause severe pathology, driven by an exaggerated immune response, infection within the inte
Document: COVID-19 was initially characterized as a disease primarily of the lungs, but it is becoming increasingly clear that the SARS-CoV2 virus is able to infect many organs and cause a broad pathological response. The primary infection site is likely to be a mucosal surface, mainly the lungs or the intestine, where epithelial cells can be infected with virus. Although it is clear that virus within the lungs can cause severe pathology, driven by an exaggerated immune response, infection within the intestine generally seems to cause minor or no symptoms. In this review, we compare the disease processes between the lungs and gastrointestinal tract, and what might drive these different responses. As the microbiome is a key part of mucosal barrier sites, we also consider the effect that microbial species may play on infection and the subsequent immune responses. Because of difficulties obtaining tissue samples, there are currently few studies focused on the local mucosal response rather than the systemic response, but understanding the local immune response will become increasingly important for understanding the mechanisms of disease in order to develop better treatments.
Search related documents:
Co phrase search for related documents- local immune response and lung damage: 1, 2
- local immune response and lung disease: 1, 2
- local lung and lung damage: 1, 2, 3, 4, 5, 6
- local lung and lung disease: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
- local lung and lung disease severity: 1
- local mucosal immune response and lung damage: 1, 2
- local site and lung disease: 1
- longitudinal analysis and lung disease: 1, 2, 3
Co phrase search for related documents, hyperlinks ordered by date