Author: Homonnay, Zalán; Jakab, Szilvia; Bali, Krisztina; Kaszab, Eszter; Mató, Tamás; Kiss, István; Palya, Vilmos; Bányai, Krisztián
Title: Genome sequencing of a novel variant of fowl adenovirus B reveals mosaicism in the pattern of homologous recombination events Cord-id: 9maowuip Document date: 2021_2_22
ID: 9maowuip
Snippet: We determined the genomic sequence of a Ukrainian strain of fowl adenovirus B (FAdV-B). The isolate (D2453/1) shared 97.2% to 98.4% nucleotide sequence identity with other viruses belonging to the species Fowl aviadenovirus B. Marked genetic divergence was seen in the hexon, fiber, and ORF19 genes, and phylogenetic analysis suggested that recombination events had occurred in these regions. Our analysis revealed mosaicism in the recombination patterns, a finding that has also been described in th
Document: We determined the genomic sequence of a Ukrainian strain of fowl adenovirus B (FAdV-B). The isolate (D2453/1) shared 97.2% to 98.4% nucleotide sequence identity with other viruses belonging to the species Fowl aviadenovirus B. Marked genetic divergence was seen in the hexon, fiber, and ORF19 genes, and phylogenetic analysis suggested that recombination events had occurred in these regions. Our analysis revealed mosaicism in the recombination patterns, a finding that has also been described in the genomes of strains of FAdV-D and FAdV-E. The shared recombination breakpoints, affecting the same genomic regions in viruses belonging to different species, suggest that similar selection mechanisms are acting on the key neutralization antigens and epitopes in viruses of different FAdV species. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00705-021-04972-9.
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