Author: Song, Gaopeng; Yang, Sen; Zhang, Wei; Cao, Yingli; Wang, Peng; Ding, Ning; Zhang, Zaihong; Guo, Ying; Li, Yingxia
Title: Discovery of the first series of small molecule H5N1 entry inhibitors. Cord-id: rd7pc0b9 Document date: 2009_1_1
ID: rd7pc0b9
Snippet: The occurrence of highly pathogenic avian influenza virus H5N1 highlights the urgent need for new classes of antiviral drugs. Inhibition of H5N1 entry into cells may be an effective strategy. We report the first three small molecule inhibitors saponins with 3-O-beta-chacotriosyl residue, which showed potent inhibitory activity with IC(50) of 7.22-9.25 microM. The subsequent SAR studies showed the 3-O-beta-chacotriosyl residue was essential for the activity, and the aglycone structure also affect
Document: The occurrence of highly pathogenic avian influenza virus H5N1 highlights the urgent need for new classes of antiviral drugs. Inhibition of H5N1 entry into cells may be an effective strategy. We report the first three small molecule inhibitors saponins with 3-O-beta-chacotriosyl residue, which showed potent inhibitory activity with IC(50) of 7.22-9.25 microM. The subsequent SAR studies showed the 3-O-beta-chacotriosyl residue was essential for the activity, and the aglycone structure also affected the activity.
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