Increased Neurite Orientation-Dispersion and Density in the TgCRND8 Mouse Model of Amyloidosis: Inverse Relation with Functional Connectome Clustering and Modulation by Interleukin-6

Luis M. Colon-Perez; Kristen R. Ibanez; Mallory Suarez; Kristin Torroella; Kelly Acuna; Edward Ofori; Yona Levites; David E. Vaillancourt; Todd E. Golde; Paramita Chakrabarty; Marcelo Febo

This was implemented within the Accelerated Microstructure Imaging via Convex Optimization (AMICO) framework (Daducci et al., 2015) , which accelerates the model fitting procedure in standard Linux PC's running Python 2.7. NODDI incorporates a multi-compartment model of the diffusion signal. The model includes an isotropic fraction of free unrestricted and hindered water (e.g., cerebral spinal fluid) and an anisotropic model that includes an intracellular fraction with zero radius infinite cylinders (high diffusion coefficients along the length of the principal axis only) and an extracellular fraction with non-zero diffusion perpendicular to the principal axis. The latter All rights reserved. No reuse allowed without permission.