Author: Luis M. Colon-Perez; Kristen R. Ibanez; Mallory Suarez; Kristin Torroella; Kelly Acuna; Edward Ofori; Yona Levites; David E. Vaillancourt; Todd E. Golde; Paramita Chakrabarty; Marcelo Febo
Title: Increased Neurite Orientation-Dispersion and Density in the TgCRND8 Mouse Model of Amyloidosis: Inverse Relation with Functional Connectome Clustering and Modulation by Interleukin-6 Document date: 2019_2_27
ID: hyeygk64_50
Snippet: To corroborate any morphological differences in WM and hippocampus across subjects as a result of IL6 or Aβ, we analyzed ROI volumes (Figure 1 ). No volumetric differences were observed between nTg and Tg or control and IL6 treatment in any ROI. However, we discovered that elevated brain IL6 significantly increased the volume of the lateral ventricles (main effect IL6 treatment: F1,43 = 63.6 p < 0.0001). The enlarged lateral ventricles were obse.....
Document: To corroborate any morphological differences in WM and hippocampus across subjects as a result of IL6 or Aβ, we analyzed ROI volumes (Figure 1 ). No volumetric differences were observed between nTg and Tg or control and IL6 treatment in any ROI. However, we discovered that elevated brain IL6 significantly increased the volume of the lateral ventricles (main effect IL6 treatment: F1,43 = 63.6 p < 0.0001). The enlarged lateral ventricles were observed in nTg and Tg mice given IL6 treatment. The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/562348 doi: bioRxiv preprint treatment F1,43 = 61 p < 0.0001). No significant effects of IL6 or Aβ were observed in genu and hippocampus.
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