Skin manifestations in COVID-19 provide a clue for disease's pathophysiology understanding.

Kubanov, A A; Deryabin, D G

The most common symptoms of COVID-19 are fever, malaise, headache, muscle pain, dry cough and pneumonia, which showed the disease as an upper respiratory tract viral infection. The first observation about COVID-19 patients who develop cutaneous manifestations was done by S. Recalcati (1). In numerous French (2), Belgian (3) Spanish (4) and Italian (5) studies, the diversity of inflammatory and vascular skin lesions in COVID-19 was described. In sum, according 46 articles data with a pooled total of 997 unique patients from 9 countries, the skin manifestations frequency up to 20,45% (6). The most commonly reported symptoms are chilblain-like (40,1%), maculopapular (23.1%) and vesicular lesions (10,1%), urticaria (21,8%), livedoid/necrotic lesions (2,3%), and other non-classified skin lesions (19,8%). Thus, the COVID-19 epidemic in Europe shows skin features as not a universal but widespread disease's manifestation, which requires to find out the relationship between the virus and the skin.