Selected article for: "anterior commissure and splenium genu"
Author: Luis M. Colon-Perez; Kristen R. Ibanez; Mallory Suarez; Kristin Torroella; Kelly Acuna; Edward Ofori; Yona Levites; David E. Vaillancourt; Todd E. Golde; Paramita Chakrabarty; Marcelo Febo
Title: Increased Neurite Orientation-Dispersion and Density in the TgCRND8 Mouse Model of Amyloidosis: Inverse Relation with Functional Connectome Clustering and Modulation by Interleukin-6
  • Document date: 2019_2_27
    • ID: hyeygk64_81
    Snippet: As with the effects of IL6 on DTI and free water metrics, the effects of this inflammatory conditioning on NODDI measures varied. IL6 increased NDI in the splenium, anterior commissure, cerebral peduncle, genu, and hippocampus, but only in nTg mice. Similar to free water results summarized above, because Aβ and IL6 were independently observed to increase NDI and ODI relative to nTg controls, we predict that both these conditions (Aβ proteinopat.....
    Document: As with the effects of IL6 on DTI and free water metrics, the effects of this inflammatory conditioning on NODDI measures varied. IL6 increased NDI in the splenium, anterior commissure, cerebral peduncle, genu, and hippocampus, but only in nTg mice. Similar to free water results summarized above, because Aβ and IL6 were independently observed to increase NDI and ODI relative to nTg controls, we predict that both these conditions (Aβ proteinopathy and IL6 inflammation) may be inducing similar microstructural changes to axons and dendritic processes in white matter and hippocampal areas.

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