Author: Pei-Hui Wang; Yun Cheng
Title: Increasing Host Cellular Receptor—Angiotensin-Converting Enzyme 2 (ACE2) Expression by Coronavirus may Facilitate 2019-nCoV Infection Document date: 2020_2_27
ID: epy7774j_31
Snippet: Overall, this study provides the first evidence that SARS-CoV, MERS-CoV and maybe 2019-nCoV can upregulate its cellular receptor ACE2 to facilitate their infection and spread. Thus, reducing ACE2 expression by siRNA or other drugs may be a direction for drug development. Because this cluster of viruses uses the same cellular receptor ACE for entering, thus preparation drugs which can reduce ACE2 expression may be useful for the future emerging in.....
Document: Overall, this study provides the first evidence that SARS-CoV, MERS-CoV and maybe 2019-nCoV can upregulate its cellular receptor ACE2 to facilitate their infection and spread. Thus, reducing ACE2 expression by siRNA or other drugs may be a direction for drug development. Because this cluster of viruses uses the same cellular receptor ACE for entering, thus preparation drugs which can reduce ACE2 expression may be useful for the future emerging infectious diseases. Our study also suggests that people infected by other viruses such as influenza or with high inflammatory cytokines may more susceptible to 2019-nCoV. This study also indicated that targeting the expression of ACE2 is a direction for drug development and infection control. The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.02.24.963348 doi: bioRxiv preprint
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