Author: Bautista-Becerril, Brandon; Campi-Caballero, Rebeca; Sevilla-Fuentes, Samuel; Hernández-Regino, Laura M.; Hanono, Alejandro; Flores-Bustamante, Al; González-Flores, Julieta; GarcÃa-Ãvila, Carlos A.; Aquino-Gálvez, Arnoldo; Castillejos-López, Manuel; Juárez-Cisneros, Armida; Camarena, Angel
Title: Immunothrombosis in COVID-19: Implications of Neutrophil Extracellular Traps Cord-id: rtnwafxw Document date: 2021_5_6
ID: rtnwafxw
Snippet: SARS-CoV-2 is a member of the family of coronaviruses associated with severe outbreaks of respiratory diseases in recent decades and is the causative agent of the COVID-19 pandemic. The recognition by and activation of the innate immune response recruits neutrophils, which, through their different mechanisms of action, form extracellular neutrophil traps, playing a role in infection control and trapping viral, bacterial, and fungal etiological agents. However, in patients with COVID-19, activati
Document: SARS-CoV-2 is a member of the family of coronaviruses associated with severe outbreaks of respiratory diseases in recent decades and is the causative agent of the COVID-19 pandemic. The recognition by and activation of the innate immune response recruits neutrophils, which, through their different mechanisms of action, form extracellular neutrophil traps, playing a role in infection control and trapping viral, bacterial, and fungal etiological agents. However, in patients with COVID-19, activation at the vascular level, combined with other cells and inflammatory mediators, leads to thrombotic events and disseminated intravascular coagulation, thus leading to a series of clinical manifestations in cerebrovascular, cardiac, pulmonary, and kidney disease while promoting severe disease and mortality. Previous studies of hospitalized patients with COVID-19 have shown that elevated levels of markers specific for NETs, such as free DNA, MPO, and H3Cit, are strongly associated with the total neutrophil count; with acute phase reactants that include CRP, D-dimer, lactate dehydrogenase, and interleukin secretion; and with an increased risk of severe COVID-19. This study analyzed the interactions between NETs and the activation pathways involved in immunothrombotic processes in patients with COVID-19.
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