Author: Chin-Yi Chu; Xing Qiu; Matthew N. McCall; Lu Wang; Anthony Corbett; Jeanne Holden-Wiltse; Christopher Slaunwhite; Qian Wang; Christopher Anderson; Alex Grier; Steven R. Gill; Gloria S. Pryhuber; Ann R. Falsey; David J. Topham; Mary T. Caserta; Edward E. Walsh; Thomas J Mariani
Title: Insufficiency in airway interferon activation defines clinical severity to infant RSV infection Document date: 2019_5_20
ID: bx49tbui_63
Snippet: Gene expression displayed an interesting association with clinical severity. No gene was marginally identified as significantly associated with severity (after adjustment for multiple testing adjustment), when severity was defined dichotomously as mild and severe. When severity was defined continuously by GRSS, 142 genes were significantly associated with GRSS. In order to better define gene expression changes independently associated with GRSS, .....
Document: Gene expression displayed an interesting association with clinical severity. No gene was marginally identified as significantly associated with severity (after adjustment for multiple testing adjustment), when severity was defined dichotomously as mild and severe. When severity was defined continuously by GRSS, 142 genes were significantly associated with GRSS. In order to better define gene expression changes independently associated with GRSS, we completed a multivariate analysis including sex, race, bacterial colonization and time since onset of clinical symptoms in the model. This analysis identified 252 genes significantly associated with disease severity (Supplemental Figure 3) . In this multivariate model, 728 genes were associated with time since illness onset and 135 genes were associated with the presence of any bacterial pathogen (Table 2) .
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