Author: Chin-Yi Chu; Xing Qiu; Matthew N. McCall; Lu Wang; Anthony Corbett; Jeanne Holden-Wiltse; Christopher Slaunwhite; Qian Wang; Christopher Anderson; Alex Grier; Steven R. Gill; Gloria S. Pryhuber; Ann R. Falsey; David J. Topham; Mary T. Caserta; Edward E. Walsh; Thomas J Mariani
Title: Insufficiency in airway interferon activation defines clinical severity to infant RSV infection Document date: 2019_5_20
ID: bx49tbui_97
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/641795 doi: bioRxiv preprint downstream signaling is critical to the protective effects of viral-induced IFN production. This interpretation is supported by our in vitro data (Fig. 5) , where blocking IFN receptor signaling is sufficient to potentiate widespread viral infection, even in the presence of IFN ligand expression. Regard.....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/641795 doi: bioRxiv preprint downstream signaling is critical to the protective effects of viral-induced IFN production. This interpretation is supported by our in vitro data (Fig. 5) , where blocking IFN receptor signaling is sufficient to potentiate widespread viral infection, even in the presence of IFN ligand expression. Regardless, induction of type I and type III IFN does occur in vivo and in vitro. The relative role of type I versus type III IFN in vivo is not clear at this time.
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