Author: Kumlin, Urban; Olofsson, Sigvard; Dimock, Ken; Arnberg, Niklas
Title: Sialic acid tissue distribution and influenza virus tropism Cord-id: ecie0dls Document date: 2008_8_8
ID: ecie0dls
Snippet: Abstract Avian influenza A viruses exhibit a strong preference for using α2,3â€linked sialic acid as a receptor. Until recently, the presumed lack of this receptor in human airways was believed to constitute an efficient barrier to avian influenza A virus infection of humans. Recent zoonotic outbreaks of avian influenza A virus have triggered researchers to analyse tissue distribution of sialic acid in further detail. Here, we review and extend the current knowledge about sialic acid distribut
Document: Abstract Avian influenza A viruses exhibit a strong preference for using α2,3â€linked sialic acid as a receptor. Until recently, the presumed lack of this receptor in human airways was believed to constitute an efficient barrier to avian influenza A virus infection of humans. Recent zoonotic outbreaks of avian influenza A virus have triggered researchers to analyse tissue distribution of sialic acid in further detail. Here, we review and extend the current knowledge about sialic acid distribution in human tissues, and discuss viruses with ocular tropism and their preference for α2,3â€linked sialic acid.
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