Author: Adriaan H. de Wilde; A. Linda Boomaars-van der Zanden; Anja W. M. de Jong; Montserrat Barcéna; Eric J. Snijder; Clara C. Posthuma
Title: Inhibition of arterivirus RNA synthesis by cyclophilin inhibitors is counteracted by mutations in replicase transmembrane subunits Document date: 2019_3_24
ID: l5n30kbm_26
Snippet: Subsequently, combining nsp5 and nsp2 mutations had a synergistic effect and confirmed the 410 importance of the common nsp2 H114R substitution for ALV resistance. Mutations in the 5'UTR and 411 nsp1 did not further reduce the sensitivity to ALV (data not shown), nor did the mutations in the 412 structural protein-coding region contribute to ALV resistance ( Fig. 9 ; Table 3 ). 413.....
Document: Subsequently, combining nsp5 and nsp2 mutations had a synergistic effect and confirmed the 410 importance of the common nsp2 H114R substitution for ALV resistance. Mutations in the 5'UTR and 411 nsp1 did not further reduce the sensitivity to ALV (data not shown), nor did the mutations in the 412 structural protein-coding region contribute to ALV resistance ( Fig. 9 ; Table 3 ). 413
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