Selected article for: "body weight and infection day"
Author: Shuai Xia; Meiqin Liu; Chao Wang; Wei Xu; Qiaoshuai Lan; Siliang Feng; Feifei Qi; Linlin Bao; Lanying Du; Shuwen Liu; Chuan Qin; Fei Sun; Zhengli Shi; Yun Zhu; Shibo Jiang; Lu Lu
Title: Inhibition of SARS-CoV-2 infection (previously 2019-nCoV) by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion
  • Document date: 2020_3_12
    • ID: j5bepvvw_33
    Snippet: In the past few decades, the viral HR1 domain has been proved to be an important were administered intranasally 0.5, 1, 2, 4, 12, and 24 h before challenge, or 0.5 and 2 579 h after challenge . Then mice were challenged intranasally with HCoV at a dose of 580 10 2 TCID50. For the viral control group, the same volume of 28% HBC or PBS was 581 administered intranasally. In each group, six mice were randomly selected for 582 euthanasia on day 5 afte.....
    Document: In the past few decades, the viral HR1 domain has been proved to be an important were administered intranasally 0.5, 1, 2, 4, 12, and 24 h before challenge, or 0.5 and 2 579 h after challenge . Then mice were challenged intranasally with HCoV at a dose of 580 10 2 TCID50. For the viral control group, the same volume of 28% HBC or PBS was 581 administered intranasally. In each group, six mice were randomly selected for 582 euthanasia on day 5 after infection, then five mice for collecting and assessing the 583 viral titer in mouse brain, one mouse for brain histological examination. Body weight 584 and survival of the remaining six mice in each group were monitored for 14 days 35 585 author/funder. All rights reserved. No reuse allowed without permission.

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