Selected article for: "core region and crystal structure"
Author: Shuai Xia; Meiqin Liu; Chao Wang; Wei Xu; Qiaoshuai Lan; Siliang Feng; Feifei Qi; Linlin Bao; Lanying Du; Shuwen Liu; Chuan Qin; Fei Sun; Zhengli Shi; Yun Zhu; Shibo Jiang; Lu Lu
Title: Inhibition of SARS-CoV-2 infection (previously 2019-nCoV) by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion
  • Document date: 2020_3_12
    • ID: j5bepvvw_6
    Snippet: To understand the structural basis of the interactions between HR1 and HR2 173 regions of SARS-CoV-2, a fusion protein containing the major parts of HR1 (residues 174 910 to 988) and HR2 (residues 1162 to 1206) with a flexible linker (L6, SGGRGG) in 175 between was constructed for crystallographic study. The crystal structure of 176 HR1-L6-HR2 shows a canonical 6-HB structure with a rod-like shape 115 Ã… in length 177 and 25 Ã… in diameter (Fig. .....
    Document: To understand the structural basis of the interactions between HR1 and HR2 173 regions of SARS-CoV-2, a fusion protein containing the major parts of HR1 (residues 174 910 to 988) and HR2 (residues 1162 to 1206) with a flexible linker (L6, SGGRGG) in 175 between was constructed for crystallographic study. The crystal structure of 176 HR1-L6-HR2 shows a canonical 6-HB structure with a rod-like shape 115 Ã… in length 177 and 25 Ã… in diameter (Fig. 2b) V1164, L1166, I1169, I1172, A1174, V1176, V1177, I1179, I1183, L1186, V1189, 183 L1193, L1197 and I1198 (Fig. 2c) . The hydrophobic interactions between HR1 and 184 HR2 are mainly located in the helical fusion core region, which will be discussed 185 later.

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