Selected article for: "lymphocyte subset and subset percentage"
Author: Hao Zhou; Wanxin Chen; Ziping Li; Bohan Yang; Qiong Zhou; Ping Wang; Jianhua Zhu; Xuexing Chen; Peng Yang
Title: Delayed-Phase Thrombocytopenia in Patients of Coronavirus Disease 2019 (COVID-19)
  • Document date: 2020_4_15
    • ID: 2my86ums_43
    Snippet: To clarify the pathogenesis of the delayed-phase thrombocytopenia, we screened laboratory results, underlining key cytokines and lymphocyte immunity. Our results suggest that IL-6, a strong inflammatory cytokine, was negatively correlated with the delayed-phase platelet count decline. This indicated that IL-6 might be an active player in the delayed-phase platelet decline. Notably, our time-correlated lymphocyte subset analysis showed B cells per.....
    Document: To clarify the pathogenesis of the delayed-phase thrombocytopenia, we screened laboratory results, underlining key cytokines and lymphocyte immunity. Our results suggest that IL-6, a strong inflammatory cytokine, was negatively correlated with the delayed-phase platelet count decline. This indicated that IL-6 might be an active player in the delayed-phase platelet decline. Notably, our time-correlated lymphocyte subset analysis showed B cells percentage was negatively associated with the delayed-phase thrombocytopenia. Since antibody production by B cells is crucial in virus protection, this result highlight an important role that antibodies play in the delayed-phase platelet decrease. We also found most of the delayed-phase thrombocytopenia lasted less than 7 days, implying the delayed-phase thrombocytopenia is transient.

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