Selected article for: "expression level and protein level"
Author: Zhenhua Zeng; Tong Sha; Yuan Zhang; Feng Wu; Hongbin Hu; Haijun Li; Jiafa Han; Wenhong Song; Qiaobing Huang; Zhongqing Chen
Title: Hypertension in patients hospitalized with COVID-19 in Wuhan, China: A single-center retrospective observational study
  • Document date: 2020_4_11
    • ID: lujxql3a_34
    Snippet: is the (which was not peer-reviewed) The copyright holder for this preprint . https://doi.org/10.1101/2020.04.06.20054825 doi: medRxiv preprint to that of ACE. ACE2 can hydrolyze angiotensin I (Ang I) to produce angiotensin (1-7) peptides, thereby generating vasodilation and lowering blood pressure. ACEI/ARB drugs may increase the protein concentration of ACE2 in rat plasma, mRNA level of ACE2, and even the activity of ACE2 in cardiac tissue 14 ......
    Document: is the (which was not peer-reviewed) The copyright holder for this preprint . https://doi.org/10.1101/2020.04.06.20054825 doi: medRxiv preprint to that of ACE. ACE2 can hydrolyze angiotensin I (Ang I) to produce angiotensin (1-7) peptides, thereby generating vasodilation and lowering blood pressure. ACEI/ARB drugs may increase the protein concentration of ACE2 in rat plasma, mRNA level of ACE2, and even the activity of ACE2 in cardiac tissue 14 . Thus, it is possible that those hypertensive patients who had been taking ACEI/ARB might have an increased level of mRNA and protein expression of ACE2 in the lungs, making them more vulnerable for SARS-COV-2 entry, as well as for development of severe COVID-19 pneumonia. These findings are worth investigating further.

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