Author: Shuai Xia; Meiqin Liu; Chao Wang; Wei Xu; Qiaoshuai Lan; Siliang Feng; Feifei Qi; Linlin Bao; Lanying Du; Shuwen Liu; Chuan Qin; Fei Sun; Zhengli Shi; Yun Zhu; Shibo Jiang; Lu Lu
Title: Inhibition of SARS-CoV-2 infection (previously 2019-nCoV) by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion Document date: 2020_3_12
ID: j5bepvvw_8
Snippet: The overall 6-HB structure of SARS-CoV-2 is similar to that of other HCoVs 187 with root-mean-square deviation (RMSD) of 0.36 Å to SARS-CoV 6-HB and 0.66 Å 188 to MERS-CoV 6-HB for all the Cα atoms (Fig. 2d) . This finding suggested that the 189 overall 6-HB conformation is an important and highly conserved component for these 190 dangerous coronaviruses. When comparing with the 6-HB of other common 191 coronaviruses causing mild respiratory d.....
Document: The overall 6-HB structure of SARS-CoV-2 is similar to that of other HCoVs 187 with root-mean-square deviation (RMSD) of 0.36 Å to SARS-CoV 6-HB and 0.66 Å 188 to MERS-CoV 6-HB for all the Cα atoms (Fig. 2d) . This finding suggested that the 189 overall 6-HB conformation is an important and highly conserved component for these 190 dangerous coronaviruses. When comparing with the 6-HB of other common 191 coronaviruses causing mild respiratory disease, such as 229E and NL63, the 192 SARS-CoV-2 6-HB has a similar overall structure, except for the different length of 193 HR2 helix in the 6-HB. The HR2 domain of 229E or NL63 forms a longer and 194 author/funder. All rights reserved. No reuse allowed without permission.
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